منابع مشابه
Infection-immunity in Experimental Salmonellosis
Salmonella enteritidis is highly virulent for the mouse causing an infection resembling mouse typhoid. Survivors of the infection are completely resistant to reinfection and eliminate a large challenge dose of virulent organisms within 72 hr. The antigenically related Salmonella gallinarum was almost avirulent for the mouse but animals vaccinated with this organism were equally capable of elimi...
متن کاملIsotype of protective anti-Salmonella antibodies in experimental mouse salmonellosis.
Mice and a rabbit were immunized with heat-killed Salmonella typhimurium bacteria or with an O-4,12 antigen-specific octasaccharide-protein conjugate. Immunoglobulin isotypes of the antisera were tested for their capacity to protect mice against experimental salmonellosis. Antibodies of immunoglobulin M + A isotypes were more protective than the immunoglobulin G antibodies in each of the two po...
متن کاملImmunization against experimental murine salmonellosis with liposome-associated O-antigen.
Partially delipidated Salmonella typhimurium (O-1,4,5,12) lipopolysaccharide was incorporated into small multilamellar liposomes composed of either naturally occurring or synthetic phospholipids. Vaccination of mice with the liposome-lipopolysaccharide complexes induced a cellular response specific for O-1,4,5,12 determinants, as determined by the development of a delayed-type hypersensitivity ...
متن کاملTreatment of experimental salmonellosis in mice with streptomycin entrapped in liposomes.
Liposome-entrapped streptomycin (SM) was compared with free SM for therapeutic efficacy against experimental salmonellosis in mice. All of the mice infected with the virulent strain of Salmonella enteritidis 116-54 died between days 5 and 7, and a dose of 20 mg of free SM per kg administered 24 h after the bacterial inoculation did not prolong the survival. In contrast, the same dose of SM entr...
متن کاملImmunity in experimental salmonellosis. 3. Comparative immunization with viable and heat-inactivated cells of Salmonella typhimurium.
Vaccination with viable cells of an avirulent Salmonella typhimurium galE mutant provides mice with solid specific immunity against subsequent infection with a virulent smooth strain. Such a live vaccine is markedly more potent than one prepared from inactivated cells of the virulent smooth strain. The superiority of the live vaccine is particularly well demonstrated when the oral route of appl...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1963
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.86.4.872-879.1963